Which of the following factors can affect the shelf life of a radiopharmaceutical?

The shelf life of a radiopharmaceutical is significantly influenced by the chemical stability of the compound. Chemical stability refers to how well the radiopharmaceutical maintains its intended structure and activity over time. Factors such as temperature, pH, and exposure to light can affect the rate at which a radiopharmaceutical may undergo degradation or chemical changes. If the chemical stability is high, the product is likely to have a longer shelf life, meaning it can remain effective and safe for use for a more extended period. Conversely, if the chemical stability is low, the radiopharmaceutical may break down quickly, leading to a shorter shelf life and potentially decreased efficacy or safety.

Other factors, while they can play a role in the overall management and effectiveness of a radiopharmaceutical, do not directly influence its inherent shelf life the way chemical stability does. For instance, patient age does not alter the physical properties of the compound itself. The storage location can affect conditions like temperature and humidity but is secondary to the compound's fundamental chemical stability characteristics. Lastly, the dosage form (e.g., liquid, powder) can influence handling and storage recommendations but does not inherently determine the longevity of the radiopharmaceutical if the chemical stability is compromised.