What is the elution efficiency if 342 mCi of Tc99m are eluted from a generator with 375 mCi on the column?

To determine the elution efficiency, the formula used is:

[ \text{Elution Efficiency} = \left( \frac{\text{Amount Eluted}}{\text{Amount Available}} \right) \times 100 ]

In this case, the amount of Tc-99m eluted is 342 mCi, and the amount available on the column is 375 mCi. Plugging these values into the formula gives:

[ \text{Elution Efficiency} = \left( \frac{342 , \text{mCi}}{375 , \text{mCi}} \right) \times 100 ]

Calculating this:

[ \text{Elution Efficiency} = \left( 0.912 \right) \times 100 = 91.2% ]

This rounds to 91%, which matches the answer choice provided.

Elution efficiency is a critical measurement in radiopharmacy as it indicates how effectively a radioactive isotope can be extracted from a generator. An efficiency of 91% suggests a high level of effectiveness, reflecting that most of the Tc-99m available could be successfully withdrawn for use in medical applications. This assessment is vital for ensuring that sufficient quantities of