According to USP criteria for MAA preparation, which statement is true?

In the preparation of macroaggregated albumin (MAA) according to USP criteria, maintaining particle size is critical for ensuring proper biodistribution and efficacy of radiopharmaceuticals.

The correct statement emphasizes that the preparation allows for some variability in particle size, specifically mentioning that some particles may be smaller than 10 microns. This is significant because MAA is used for imaging techniques and therapeutic applications, and having a certain proportion of smaller particles can influence their behavior in the vascular system, affecting transit and clearance from the lungs or target organs.

Selecting a particle size range helps ensure that when MAA is administered, it effectively reaches the desired anatomical locations without causing blockages or other complications, hence the allowance of smaller particles in the preparation.

Other statements regarding the specifications for particle size either impose stricter limits or incorrect uniformity which does not reflect the actual practice in the preparation of MAA. Understanding these size specifications is essential in meeting safety and efficacy standards for MAA in clinical applications.